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The Evolution of HIV

edited by Keith A. Crandall

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The HIV epidemic has spawned a scientific effort unprecedented in the history of infectious disease research. This effort has merged aspects of clinical research, basic molecular biology, immunology, cell biology, epidemiology, and mathematical biology in ways that have not been seen before. In The Evolution of HIV Keith A. Crandall brings together researchers from these disciplines to present perspectives on both the molecular biology and molecular evolution of HIV.

The book is organized into three sections: "Introduction to HIV" explores the fundamentals of the virus's molecular biology and...

The HIV epidemic has spawned a scientific effort unprecedented in the history of infectious disease research. This effort has merged aspects of clinical research, basic molecular biology, immunology, cell biology, epidemiology, and mathematical biology in ways that have not been seen before. In The Evolution of HIV Keith A. Crandall brings together researchers from these disciplines to present perspectives on both the molecular biology and molecular evolution of HIV.

The book is organized into three sections: "Introduction to HIV" explores the fundamentals of the virus's molecular biology and its global diversity. "Molecular Methods for Studying HIV Diversity" looks at such topics as HIV phylogenetics, modeling the molecular evolution of HIV sequences, the use of phylogenetic inference to test an HIV transmission hypothesis, and coalescent approaches to HIV population genetics. The third section,"Case Studies of HIV Evolution" examines the levels of diversity within and among host individuals, the phylogenetics of known transmission histories, and HIV evolution and disease progression via longitudinal studies.

The book will be of interest to researchers and clinicians working on HIV, as well as scientists studying molecular evolution, population genetics, and evolutionary biology. Contributors are John M. Coffin, Keith A. Crandall, Joseph Felsenstein, Walter M. Fitch, Brian Foley, Esther Guzman, Paul H. Harvey, David M. Hillis, Edward C. Holmes, Marcia L. Kalish, Bette T. M. Korber, Julia Krushkal, Carla L. Kuiken, Gerald H. Learn, Thomas Leitner, Wen-Hsiung Li, Francine E. McCutchan, Spencer V. Muse, Oliver G. Pylons, Allen G. Rodrigo, Raj Shankarappa, Richard W. Steketee, Alan R. Templeton, Donald M. Thea, Raphael P. Viscidi, Steven M. Wolinsky.

Reviews

Reviews

As a model for viral evolution, this book is a gold mine. [It] should be used as a starting point for those who want to browse the huge literature on the subject... [and] to those who devise policies for the containment of the epidemic.

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Book Details

Publication Date
Status
Available
Trim Size
6
x
9
Pages
520
ISBN
9780801861512
Illustration Description
53 b&w illus.
Table of Contents

Contributors
Preface
Part I: Introduction to HIV
Chapter 1. Molecular Biology of HIV
Chapter 2. Global Diversity in HIV
Part II: Molecular Methods For Studying HIV Diversity
Chapter 3. Phylogenetics and the

Contributors
Preface
Part I: Introduction to HIV
Chapter 1. Molecular Biology of HIV
Chapter 2. Global Diversity in HIV
Part II: Molecular Methods For Studying HIV Diversity
Chapter 3. Phylogenetics and the Study of HIV
Chapter 4. Modeling the Molecular Evolution of HIV Sequeuences
Chapter 5. Statistical Approaches to Detecting Recombination
Chapter 6. The Molecular Population Dynamics of HIV-1
Chapter 7. Use of Phylogenetic Inference to Test an HIV Transmission Hypothesis
Chapter 8. Coalescent Approaches to HIV Population Genetics
Part III: Case Studies of HIV Evolution
Chapter 9. Levels of Diversity Within and Among Host Individuals
Chapter 10. The Phylogenetics of Known Transmission Histories
Chapter 11. HIV Evolution and Disease Progression Via Longitudinal Studies
Chapter 12. Perinatal HIV Infection
Chapter 13. Determinants of HIV-1 Protein Evolution
Chapter 14. Evolution of HIV-1 Resistance to Antiviral Agents
Index

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