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Building Breakthroughs

On the Frontier of Medical Innovation

Raju Prasad

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From mRNA vaccines to gene therapies, the next frontier of medical innovation is here.

In Building Breakthroughs, Raju Prasad tells the story of important advancements in biotechnology and medical innovation from gene therapies to mRNA vaccines, providing historical context and examining cutting-edge research. Based on in-depth interviews with both the scientists who developed these discoveries and the patients who have benefitted from them, Building Breakthroughs reveals the key players behind drug development and the inner workings of this essential business.

Through stories of patients and…

From mRNA vaccines to gene therapies, the next frontier of medical innovation is here.

In Building Breakthroughs, Raju Prasad tells the story of important advancements in biotechnology and medical innovation from gene therapies to mRNA vaccines, providing historical context and examining cutting-edge research. Based on in-depth interviews with both the scientists who developed these discoveries and the patients who have benefitted from them, Building Breakthroughs reveals the key players behind drug development and the inner workings of this essential business.

Through stories of patients and their families, and of the researchers creating new treatments, Prasad reveals how cell therapies are advancing to treat childhood leukemia and a form of lymphoma, how a gene therapy was established to treat the rare disease spinal muscular atrophy type I, and potentially curative therapies that are being developed for sickle cell disease. By examining the clinical trial and regulatory paths each therapy took to reach approval, Prasad uncovers the building blocks of biotechnology innovation and the investments that must be made to catalyze the development of future breakthroughs. He also explores issues of scientific communication and misinformation, providing recommendations for improvements in the future.

For those seeking to understand the vitally important processes that lead to new medicines and the surrounding ecosystem that is enabling the next generation of innovative medicines that have the potential to transform patient outcomes, Building Breakthroughs is essential reading.

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Raju Prasad

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Prasad has woven together a book that is rich in detail and brings to life compelling stories about both patients and the medicines that have helped them.

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Book Details

Release Date
Publication Date
Status
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Trim Size
6
x
9
Pages
240
ISBN
9781421444871
Table of Contents

Introduction
Part I. The Journey from Idea to Approval
Chapter 1. Leukemia and Lymphoma
Chapter 2. Chimeric Antigen Receptor (CAR)-T Cell Therapy
Chapter 3. Spinal Muscular Atrophy
Chapter 4. In Vivo Gene

Introduction
Part I. The Journey from Idea to Approval
Chapter 1. Leukemia and Lymphoma
Chapter 2. Chimeric Antigen Receptor (CAR)-T Cell Therapy
Chapter 3. Spinal Muscular Atrophy
Chapter 4. In Vivo Gene Therapy
Chapter 5. Sickle Cell Anemia
Chapter 6. Ex Vivo Gene-Modified Cell Therapy
Chapter 7. A Brief History of FDA Regulation
Chapter 8. The Path to Approval
Part II. Enabling the Next Wave Of Innovation
Chapter 9. Building Blocks
Chapter 10. Recognizing Value
Chapter 11. Financial and Human Capital Investments in Biotechnology
Chapter 12. Looking Forward
Epilogue. COVID-19
Acknowledgments
References
Index

Author Bio
Featured Contributor

Raju Prasad

Raju Prasad, PhD (CHICAGO, IL), is a partner and biotechnology analyst at William Blair, focusing on cell therapy, gene therapy, and gene editing. Dr. Prasad previously worked as a research associate with the University of North Carolina at Chapel Hill's Gillings School of Global Public Health and as an independent consultant with the US Environmental Protection Agency.