Back to Results
Cover image of The Antibiotic Era
Cover image of The Antibiotic Era
Share this Title:

The Antibiotic Era

Reform, Resistance, and the Pursuit of a Rational Therapeutics

Scott H. Podolsky

Publication Date
Binding Type

A compelling analysis of nearly seven decades of antibiotic reform, framing our current efforts to stave off a post-antibiotic era.

Winner of the CHOICE Outstanding Academic Title of the Choice ACRL

In The Antibiotic Era, physician-historian Scott H. Podolsky narrates the far-reaching history of antibiotics, focusing particularly on reform efforts that attempted to fundamentally change how antibiotics are developed and prescribed. This sweeping chronicle reveals the struggles faced by crusading reformers from the 1940s onward as they advocated for a rational therapeutics at the crowded...

A compelling analysis of nearly seven decades of antibiotic reform, framing our current efforts to stave off a post-antibiotic era.

Winner of the CHOICE Outstanding Academic Title of the Choice ACRL

In The Antibiotic Era, physician-historian Scott H. Podolsky narrates the far-reaching history of antibiotics, focusing particularly on reform efforts that attempted to fundamentally change how antibiotics are developed and prescribed. This sweeping chronicle reveals the struggles faced by crusading reformers from the 1940s onward as they advocated for a rational therapeutics at the crowded intersection of bugs and drugs, patients and doctors, industry and medical academia, and government and the media.

During the post–World War II "wonder drug" revolution, antibiotics were viewed as a panacea for mastering infectious disease. But from the beginning, critics raised concerns about irrational usage and overprescription. The first generation of antibiotic reformers focused on regulating the drug industry. The reforms they set in motion included the adoption of controlled clinical trials as the ultimate arbiters of therapeutic efficacy, the passage of the Kefauver-Harris amendments mandating proof of drug efficacy via well-controlled studies, and the empowering of the Food and Drug Administration to remove inefficacious drugs from the market. Despite such victories, no entity was empowered to rein in physicians who inappropriately prescribed, or overly prescribed, approved drugs.

Now, in an era of emerging bugs and receding drugs, discussions of antibiotic resistance focus on the need to develop novel antibiotics and the need for more appropriate prescription practices in the face of pharmaceutical marketing, pressure from patients, and the structural constraints that impede rational delivery of antibiotics worldwide. Concerns about the enduring utility of antibiotics—indeed, about a post-antibiotic era—are widespread, as evidenced by reports from the Centers for Disease Control and Prevention, academia, and popular media alike. Only by understanding the historical forces that have shaped our current situation, Podolsky argues, can we properly understand and frame our choices moving forward.

Reviews

Reviews

The author deftly handles the debates that festered around the appropriate roles of industry, clinicians and government in the production and use of antibiotics... The work is scholarly, exceptionally well researched, and worthy of serious examination for those interested in past, current and future efforts to frame and inform the public about antibiotic-resistant bacteria.

... this book is a fascinating reminder that the benefits of antibiotics were squandered right from the beginning of the antibiotic era.

The Antibiotic Era is about more than just antibiotics per se: it is also a rich and deeply thoughtful exploration of the contested process by which notions of therapeutic rationality have been developed, enacted, and resisted. As such, it should be read by both historians and other scholars of recent American medicine and by those interested in the use and misuse of antibiotics more broadly.

With access to a wide range of archives from government agencies and academia, Podolsky takes us through a host of conferences, councils, courts, congressional hearings, symposia and task forces to reveal the tensions that grew since the 1940s between the pharmaceutical industry and medical academia, patients and doctors, and government and the media concerning over-marketed and irrationally prescribed antibiotics.

See All Reviews
About

Book Details

Publication Date
Status
Available
Trim Size
6
x
9
Pages
328
ISBN
9781421415932
Illustration Description
18 halftones, 7 line drawings
Table of Contents

Acknowledgments
Introduction
1. The Origins of Antibiotic Reform
2. Antibiotics and the Invocation of the Controlled Clinical Trial
3. From Sigmamycin to Panalba
4. "Rational" Therapeutics and the Limits

Acknowledgments
Introduction
1. The Origins of Antibiotic Reform
2. Antibiotics and the Invocation of the Controlled Clinical Trial
3. From Sigmamycin to Panalba
4. "Rational" Therapeutics and the Limits to Delimitation
5. Responding to Antibotic Resistance
Conclusion
List of Abbreviations
Notes
Index

Author Bio
Featured Contributor

Scott H. Podolsky

Scott H. Podolsky is an internist at Massachusetts General Hospital, professor of global health and social medicine at Harvard Medical School, and the director of the Center for the History of Medicine at the Francis A. Countway Library of Medicine.
Resources